Sr. Associate Scientist / Scientist I, Protein Engineering



South San Francisco, CA, USA
Posted on Friday, March 31, 2023

Therapeutics - Drug Discovery

South San Francisco, California, United States

Who We Are

23andMe, the leading consumer genetics and research company, has accumulated a wealth of genotypic and phenotypic information from participants committed to improving human health through advances in genomics. Our Therapeutics team in South San Francisco leverages this data to discover and develop new treatments that can offer significant benefits for patients with serious, unmet medical needs.

This dedicated research and drug development group identifies novel targets using 23andMe's genetic database and performs preclinical research to advance programs towards clinical development. We currently have programs across several therapeutic areas, including but not limited to oncology, respiratory, and cardiovascular diseases. More information about our Therapeutics team is available at

We are seeking an exceptional, highly-motivated Sr. Associate Scientist or Scientist I to contribute to a collaborative, cross-functional research team responsible for expression, purification and biochemical/biophysical characterization of antibodies and diverse protein targets.

In-depth technical expertise with recombinant protein expression, purification and characterization is required. Successful candidates will also be independent and creative researchers, capable of experimental design, execution and troubleshooting.

What You'll Do

  • Help manage the production of mammalian proteins and antibodies to support therapeutic development programs, from construct generation through purification and biophysical/analytical characterization
  • Interface and collaborate closely with other functional teams, including Analytics, Antibody Engineering, and Biology
  • Consult with project leads to manage and prioritize protein reagent requirements for multiple projects
  • Utilize mammalian (HEK293 & CHO), insect (Baculovirus) and bacterial (E.coli) transient expression systems for protein production
  • Perform protein purification using a broad variety of chromatographic methods utilizing FPLC/AKTA systems
  • Produce, engineer, label and/or optimize protein reagents for use in biochemical and functional screening assays
  • Manage CRO workflows and progress on protein expression/purification related projects
  • Generate, analyze, document and communicate high quality data

What You’ll Bring

  • Masters with minimum of 6 years of relevant experience or PhD degree with research experience in Structural biology, Biochemistry, Protein engineering or related field
  • Experience with protein structure analysis and protein design
  • Successful track record in optimizing and troubleshooting difficult-to-express/purify proteins
  • Extensive hands-on experience with mammalian (transient/stable), insect (baculovirus), and e.coli expression systems
  • Strong technical expertise in protein purification (secreted, membrane, soluble, and insoluble proteins using various chromatography techniques) and characterization (HPLC-SEC (FSEC), DSF, ELISA, Octet and/or Biacore, etc.)
  • Critical thinking with a high degree of innovative and analytical skills
  • Excellent organizational and communication skills with the ability to work independently and collaboratively in a fast-paced team environment

Strongly Preferred

  • Biotech or pharma work experience
  • Experience with membrane protein purification and characterization for structural biology
  • Experience with modeling protein interactions with proteins/small molecules/antibodies using computational approaches
  • Experience working in an antibody and/or small molecule discovery/development setting
  • Experience with protein evolution technologies like phage display

Note: Job title will be commensurate with experience and academic credentials.

About Us

23andMe, headquartered in Sunnyvale, CA, is a leading consumer genetics and research company. Founded in 2006, the company’s mission is to help people access, understand, and benefit from the human genome. 23andMe has pioneered direct access to genetic information as the only company with multiple FDA authorizations for genetic health risk reports. The company has created the world’s largest crowdsourced platform for genetic research, with 80 percent of its customers electing to participate. The platform also powers the 23andMe Therapeutics group, currently pursuing drug discovery programs rooted in human genetics across a spectrum of disease areas, including oncology, respiratory, and cardiovascular diseases, in addition to other therapeutic areas. More information is available at

At 23andMe, we value a diverse, inclusive workforce and we provide equal employment opportunity for all applicants and employees. All qualified applicants for employment will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application because of incompatible assistive technology or a disability, please contact us at 23andMe will reasonably accommodate qualified individuals with disabilities to the extent required by applicable law.

Please note: 23andMe does not accept agency resumes and we are not responsible for any fees related to unsolicited resumes. Thank you.

Pay Transparency
23andMe takes a market-based approach to pay, and amounts will vary depending on your geographic location. The salary range reflected here is for a candidate based in the San Francisco Bay Area. The successful candidate’s starting pay will be determined based on job-related skills, experience, qualifications, work location, and market conditions. These ranges may be modified in the future.
San Francisco Bay Area Base Pay Range
Senior Associate Scientist: $115,000-$173,000 USD
Scientist I: $128,000-$192,000 USD